2017~2007

研究成果

Cover_image00

Blood., 123(25):3963-71, 2014, 表紙

Cover_image00

Cold Spring Harb Perspect
Biol., 6(6), 2014, 表紙

Cover_image01

アポトーシスとさまざまな細胞死
メディカル・サイエンス・インターナショナル

research_image01

Journal of Leukocyte Biology,
vol.83(5),2008, 表紙

research_image01

Molecular Biology of the Cell
(5th edition) DVD
細胞がアポトーシスを起こす様子が
ムービーで掲載されています。

2017

Yanagihashi Y, Segawa K, Maeda R, Nabeshima Y-i, and Nagata S.

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis.

Proc Nat Acad Sci USA:in press.

Gyobu S, Ishihara K, Suzuki J, Segawa K, and Nagata S.

Characterization of the scrambling domain of the TMEM16 family.

Proc. Natl. Acad. Sci. USA 114:6274-6279.

Nagata, S. and Tanaka, M.

Programmed cell death and the immune system.

Nat Rev Immunol 17:333-340

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S., and Kurose, H.

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.

J Clin Invest: 127: 383-401, 2017

2016

Suzuki, J., Imanishi, E., and Nagata, S.

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

Proc. Natl. Acad. Sci. USA 113: 9509-9514, 2016

Sakamoto, K., Fukushima, Y., Ito, K., Matsuda, M., Nagata, S., Minato, N., and Hattori, M.

Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.

J. Immunol. 197: 2177-2186, 2016

Ishihara, K., Suzuki, J. and Nagata, S.

A Role of Ca2+ in the Stability and Function of TMEM16F and 16K.

Biochemistry 55: 3180-3188, 2016

Nagata, S.

Cell biology: Killer enzymes tethered.

Nature 533: 474-476, 2016

Segawa, K., Kurata, S., and Nagata, S.

Human type IV P-type ATPases that work as plasma membrane phospholipid flippases, and their regulation by caspase and calcium.

J. Biol. Chem. 291 (2): 762-772, 2016

Gyobu, S., Miyata, H., Ikawa, M., Yamazaki, D., Takeshima, H., Suzuki, J., and Nagata, S.

A role of TMEM16E carrying a scrambling domain in sperm motility.

Mol. Cell Biol. 36: 645-659, 2016

Nagata, S., Suzuki, J., Segawa, K., and Fujii, T.

Exposure of Phosphatidylserine on the Cell Surface.

Cell Death Differ. 23: 952-961, 2016

2015

Fujii, T., Sakata, A., Nishimura, S., Eto, K., and Nagata, S.

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.

Proc. Natl. Acad. Sci. USA 112 (41): 12800-12805, 2015

Segawa, K., and Nagata, S.

An apoptotic 'eat me' signal: phosphatidylserine exposure.

Trends Cell Biol 25: 649-650, 2015

Toda, S., Nishi, C., Yanagihashi, Y., Segawa, K., and Nagata, S.

Clearance of Apoptotic Cells and Pyrenocytes.

Curr. Top. Dev. Biol. 114: 267-295, 2015

Motani, K., Ito, S., and Nagata, S.

DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.

J Immunol. 194(10):4914-23., 2015

2014

Suzuki, J., Imanishi, E. and Nagata, S.

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

J. Biol. Chem., 289(44):30257-30267, 2014

Segawa, K., Suzuki, J. and Nagata, S.

Flippases and scramblases in the plasma membrane.

Cell Cycle, 13(19):2990-2991, 2014

Chaffee, B.R, Shang, F., Chang, M., Clement, T.M., Eddy, E.M., Wagner, B.D., Nakahara,M., Nagata, S., Robinson, M.L. and Taylor, A.

uclear Removal during Terminal Lens Fiber Cell Differentiation Requires CDK1 Activity: AppropriatingMitosis-Related Nuclear Disassembly.

Development, 141(17):3388-3398, 2014

Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, TR., Matsuda, F. and Nagata, S.

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

Science, 344: 1164-1168, 2014

Yamaguchi, H., Maruyama, T., Urade, Y. and Nagata, S.

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.

eLife., 3: e02172, 2014

Toda, S., Segawa, K. and Nagata, S.

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands.

Blood., 123(25):3963-3971, 2014

Nishi, C., Toda, S., Segawa, K. and Nagata, S.

Tim4- and MerTK- mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages.

Mol Cell Biol., 34: 1512-1520, 2014

Kawane, K., Motani, K. and Nagata, S.

DNA Degradation and Its Defects.

Cold Spring Harb Perspect Biol., 6(6): pii a016394, 2014

Suzuki, T., Suzuki, J. and Nagata, S.

Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F.

J Biol Chem., 289: 7438-7447, 2014

Yamamoto, N., Yamaguchi, H., Ohmura, K., Yokoyama, T., Yoshifuji, H., Yukawa, N., Kawabata, D., Fujii, T., Morita, S., Nagata, S. and Mimori, T.

Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets.

Lupus, 23: 386-394, 2014

Suzuki, J. and Nagata, S.

Phospholipid scrambling on the plasma membrane.

Methods Enzymol., 544:381-393, 2014

2013

Suzuki, J., Denning, DP., Imanishi, E., Horvitz, HR. and Nagata, S.

Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.

Science, 341: 403-406, 2013

Lauber, K., Keppeler, H., Munoz, LE., Koppe, U., Schroder, K., Yamaguchi, H., Kronke, G., Uderhardt, S., Wesselborg, S., Belka, C., Nagata, S. and Herrmann, M.

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.

Cell Death Differ, 20: 1230-40, 2013

Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H., and Nagata, S.

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Family Members.

J. Biol. Chem., 288: 13305-13316, 2013

Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S. and Suda, T.

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.

Int Immunol., 25: 363-372, 2013

Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Safig, P., Peters, C., Nagata, S., and Uchiyama, Y.

Biogenesis and Proteolytic Processing of Lysosomal DNase II.

PLoS One 8: e59148, 2013

Imao, T. and Nagata, S.

Apaf-1- and Caspase-8-independent apoptosis.

Cell Death Differ, 20: 343-352, 2013

2012

Liu, X., Sano, T., Guan, Y., Nagata, S. Hoffmann, JA. and Fukuyama,H.

Drosophila EYA Regulates the Immune Response against DNA through an Evolutionarily Conserved Threonine Phosphatase Motif.

PloS One,7: e42725, 2012

Miyanishi, M. Segawa, K. and Nagata, S.

Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity.

Int Immunol.,24: 551-9, 2012

Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano- Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.

J Exp. Med.,209: 1493-1503, 2012

Alonzo M., Lacuesta T., Dimaano EM., Kurosu T., Suarez LC.,Mapua CA., Akeda Y., Matias RR., Kuter DJ., Nagata S., Natividad FF. and Oishi K.

Platelet Apoptosis and Apoptotic Platelet Clearance by Macrophages in Secondary Dengue Virus Infections.

J Infect Dis. 205, 1321-1329 (2012)

Toda S., Hanayama R. and Nagata S.

Two-step engulfment of apoptotic cells.

Mol Cell Biol. 32, 118-125 (2012)

2011

Nagata S. and Kawane K.

Autoinflammation by endogenous DNA.

Adv. Immunol. 110, 139-161 (2011)

Segawa K., Suzuki J. and Nagata S.

Constitutive exposure of phosphatidylserine on viable cells.

Proc. Natl. Acad. Sci. U.S.A. 108, 19246-19251 (2011)

Sano T. and Nagata S.

Characterization of the threonine-phosphatase of mouse eyes absent 3.

FEBS Lett. 585, 2714-2719 (2011)

2010

Suzuki J., Umeda M., Sims P.J. and Nagata S.

Calcium-dependent phospholipid scrambling by TMEM16F.

Nature. 468, 834-838 (2010).

Kawane K., Tanaka H., Kitahara Y., Shimaoka S., and Nagata S.

Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation

Proc. Natl. Acad. Sci. U. S. A. 107,19432-19437 (2010).

Ostberg T., Kawane K., Nagata S., Yang H., Chavan S., Klevenvall L., Bianchi M., Harris H. E., Andersson U. and Palmblad K.

Protective targeting of HMGB1 in a spontaneous arthritis model

Arthritis Rheum. 62, 2963-2972 (2010).

Nagata S.

Apoptosis and autoimmune diseases.

Annals. NY Acad. Sci. 1209, 10-16 (2010).

Kitahara Y., Kawane K. and Nagata S.

Interferon-induced TRAIL-independent cell death in DNase II(-/-) embryos.

Eur. J. Immunol. 40, 2590-2598 (2010).

Fujii T., Ueda T., Nagata S. and Fukunaga R.

Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression.

J. Biol. Chem. 285, 30214-30223 (2010).

Yamaguchi H., Fujimoto T., Nakamura S., Ohmura K., Mimori T., Matsuda F. and Nagata S.

Aberrant splicing of milk fat globule EGF factor 8 gene in human systemic lupus erythematosus

Eur. J. Immunol. 40, 1778-1785 (2010).

Nagasaka A., Kawane K., Yoshida H. and Nagata S.

Apaf-1-independent programmed cell death in mouse development

Cell Death Differ. 17, 931-941 (2010).

Nagata S., Hanayama R. and Kawane K.

Autoimmunity and the Clearance of Dead Cells.

Cell 140, 619-630 (2010).

2009

Strasser A., Jost P. J. and Nagata S.

The many roles of FAS receptor signaling in the immune system.

Immunity 30, 180-92. (2009).

Okabe Y., Sano T. and Nagata S.

Regulation of the innate immune response by threonine-phosphatase of Eyes absent.

Nature 460, 520-524. (2009).

Hanayama R., Miyanishi M., Yamaguchi H., Suzuki J. and Nagata S.

Engulfment of apoptotic cells and its physiological roles.

Cell Death, G. Melino and D.Vaux, eds. (John Wiley & Sons) 165-175 (2009).

Galluzzi L., Aaronson S. A., Abrams J., Alnemri E. S., Andrews D. W., Baehrecke E. H. et al.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Cell Death Differ. 16, 1093-1107. (2009).

Dasgupta S. K., Abdel-Monem H., Niravath P., Le A., Bellera R. V., Langlois K., Nagata S., Rumbaut R. and Thiagarajan P.

Lactadherin and clearance of platelet-derived microvesicles

Blood 113, 1332-1339. (2009).

2008

Yamaguchi H., Takagi J., Miyamae T., Yokota S., Fujimoto T., Nakamura S., Oshima S., Naka T., and Nagata S.

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus

J. Leukoc. Biol. 83, 1300-1307. (2008).

Okabe Y., Kawane K. and Nagata S.

IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.

Eur. J. Immunol. 38, 3150-3158. (2008).

Nakaya M., Kitano M., Matsuda M. and Nagata S.

Spatiotemporal activation of Rac1 for engulfment of apoptotic cells

Proc. Natl. Acad. Sci. U. S. A. 105, 9198-9203. (2008).

Nagata, S.

Rheumatoid polyarthritis caused by a defect in DNA degradation

Cytokine Growth Factor Rev. 19, 295-302. (2008).

Koike M., Shibata M., Tadakoshi M., Gotoh K., Komatsu M., Waguri S., Kawahara N., Kuida K., Nagata S., Kominami E., Tanaka K. and Uchiyama Y.

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

Am. J. Pathol. 172, 454-469. (2008).

Kitano M., Nakaya M., Nakamura T., Nagata S. and Matsuda M.

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Nature 453, 241-245. (2008).

Kawane K.and Nagata S.

Nucleases in programmed cell death

Methods Enzymol. 442, 271-287. (2008).

Iida S., Watanabe-Fukunaga R., Nagata S. and Fukunaga R.

Essential role of C/EBP alpha in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes

Genes Cells 13, 313-327. (2008).

Dasgupta S. K., Abdel-Monem H., Guchhait P., Nagata S. and Thiagarajan P.

Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cells

Transfusion 48, 2370-2376. (2008).

2007

Witasp E., Uthaisang W., Elenstrom-Magnusson C., Hanayama R., Tanaka M., Nagata S., Orrenius S. and Fadeel B.

Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target

Cell Death Differ. 14, 1063-1065. (2007).

Ueda T., Watanabe-Fukunaga R., Ogawa H., Fukuyama H., Higashi Y., Nagata S. and Fukunaga R.

Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis

Genes Cells 12, 581-592. (2007).

Nakahara M., Nagasaka A., Koike M., Uchida K., Kawane K., Uchiyama Y. and Nagata S.

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

Febs Journal 274, 3055-3064. (2007).

Nagata S.

Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors

Immunol. Rev. 220, 237-250. (2007).

Miyanishi M., Tada K., Koike M., Uchiyama Y., Kitamura T. and Nagata S.

Identification of Tim4 as a phosphatidylserine receptor

Nature 450, 435-439. (2007).

return top

2011~2007