Biochemistry & Immunology,Immunology Frontier Research Center, Osaka University

Takakuwa T., Dong Z. M., Nakatsuka S., Kojka S., Harabuchi Y., Yang W. I. Nagata S. and Aozasa K.

Frequent mutations of Fas gene in nasal NK/T cell lymphoma

Oncogene 21, 4702-4705. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/12096347?

Shimizu M., Fukuo K., Nagata S., Suhara T., Okuro M., Fujii K., Higashino Y., Mogi M., Hatanaka Y. and Ogihara T.

Increased plasma levels of the soluble form of Fas ligand in patients with acute myocardial infarction and unstable angina pectoris

J. Am. Coll. Cardiol. 39, 585-590. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/11849855?

Sakahira H. and Nagata S.

Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase

J. Biol. Chem. 277, 3364-3370. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/11724800?

Nagata S.

Breakdown of chromosomal DNA

Cornea 21, S2-6. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/11995805?

Mukae N., Yokoyama H., Yokokura T., Sakoyama Y. and Nagata S.

Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation

Genes Dev. 16, 2662-2671. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/12381665?

Koike H., Horie K., Fukuyama H., Kondoh G., Nagata S. and Takeda J.

Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination

Embo Reports 3, 433-437. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/11964386?

Hanayama R., Tanaka M., Miwa K., Shinohara A., Iwamatsu A. and Nagata S.

Identification of a factor that links apoptotic cells to phagocytes

Nature 417, 182-187. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/12000961?

Fukuyama H., Adachi M., Suematsu S., Miwa K., Suda T., Yoshida N. and Nagata S.

Requirement of Fas expression in B cells for tolerance induction

Eur. J. Immunol. 32, 223-230. (2002).

http://www.ncbi.nlm.nih.gov/pubmed/11782013?

Takayama H., Takakuwa T., Dong Z. M., Nonomura N., Okuyama A., Nagata S. and Aozasa K.

Fas gene mutations in prostatic: Intraepithelial neoplasia and concurrent carcinoma: Analysis of laser capture microdissected specimens

Lab. Invest. 81, 283-288 (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11310821?

Takakuwa T., Dong Z. M., Takayama H., Matsuzuka F., Nagata S. and Aozasa K.

Frequent mutations of Fas gene in thyroid lymphoma

Cancer Res. 61, 1382-1385. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11245438?

Shudo K., Kinoshita K., Imamura R., Fan H., Hasumoto K., Tanaka M., Nagata S. and Suda T.

The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity

Eur. J. Immunol. 31, 2504-2511. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11500835?

Sakahira H., Takemura Y. and Nagata S.

Enzymatic active site of caspase-activated DNase (CAD) and its inhibition by inhibitor of CAD

Arch. Biochem. Biophys. 388, 91-99. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11361146?

Kawane K., Fukuyama H., Kondoh G., Takeda J., Ohsawa Y., Uchiyama Y. and Nagata S.

Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

Science 292, 1546-1549. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11375492?

Itai T., Tanaka M. and Nagata S.

Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form

Eur. J. Biochem. 268, 2074-2082. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11277930?

Fukumoto T., Watanabe-Fukunaga R., Fujisawa K., Nagata S. and Fukunaga R.

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

J. Biol. Chem. 276, 38441-38448. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11495917?

D'Alessio A., Riccioli A., Lauretti P., Padula F., Muciaccia B., De Cesaris P., Filippini A., Nagata S. and Ziparo E.

Testicular FasL is expressed by sperm cells

Proc. Natl. Acad. Sci. U. S. A. 98, 3316-3321. (2001).

http://www.ncbi.nlm.nih.gov/pubmed/11248076?

Yokoyama H., Mukae N., Sakahira H., Okawa K., Iwamatsu A. and Nagata S.

A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster

J. Biol. Chem. 275, 12978-12986. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10777599?

Ueno Y., Ishii M., Yahagi K., Mano Y., Kisara N., Nakamura N., Shimosegawa T., Toyota T. and Nagata S.

Fas-mediated cholangiopathy in the murine model of graft versus host disease

Hepatology 31, 966-974. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10733554?

Uegaki K., Otomo T., Sakahira H., Shimizu M., Yumoto N., Kyogoku Y., Nagata S. and Yamazaki T.

Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor

J. Mol. Biol. 297, 1121-1128. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10764577?

Tamada K., Shimozaki K., Chapoval A. I., Zhu G. F., Sica G., Flies D., Boone T., Hsu H.L., Fu Y.X., Nagata S., Ni J. and Chen L.P.

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

Nat. Med. 6, 283-289. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10700230?

Tamada K., Shimozaki K., Chapoval A. I., Zhai Y. F., Su J., Chen S. F., Hsieh S.L., Nagata S., Ni J., and Chen L.P.

LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

J. Immunol. 164, 4105-4110. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10754304?

Sotozono C., Sano Y., Suzuki T., Tada R., Ikeda T., Nagata S. and Kinoshita S.

Soluble Fas ligand expression in the ocular fluids of uveitis patients

Curr. Eye Res. 20, 54-57. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10611715?

Sakamaki K., Kanda N., Ueda T., Aikawa E. and Nagata S.

The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17

Cytogenet. Cell Genet. 88, 246-248. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10828600?

Sakahira H., Iwamatsu A. and Nagata S.

Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase

J. Biol. Chem. 275, 8091-8096. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10713130?

Ryo K., Kamogawa Y., Ikeda I., Yamauchi K., Yonehara S., Nagata S. and Hayashi N.

Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure

Am. J. Gastroenterol. 95, 2047-2055. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10950056?

Otomo T., Sakahira H., Uegaki K., Nagata S. and Yamazaki T.

Structure of the heterodimeric complex between CAD domains of CAD and ICAD

Nat. Struct. Biol. 7, 658-662. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10932250?

Okuda Y., Sakoda S., Fujimura H., Nagata S., Yanagihara T. and Bernard C. C. A.

Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis.

Biochem. Biophys. Res. Commun. 275, 164-168 (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10944459?

Nagata S.

Apoptotic DNA fragmentation

Exp. Cell Res. 256, 12-18. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10739646?

Nagata S.

Steering anti-cancer drugs away from the TRAIL

Nat. Med. 6, 502-503. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10802698?

Munsch D., Watanabe-Fukunaga R., Bourdon J. C., Nagata S., May E., Yonish-Rouach E. and Reisdorf P.

Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis

J. Biol. Chem. 275, 3867-3872. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10660538?

Mukae N., Yokoyama H., Yokokura T., Sakoyama Y., Sakahira H. and Nagata S.

Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster

J. Biol. Chem. 275, 21402-21408. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10781612?

Morita Y., Naka T., Kawazoe Y., Fujimoto M., Narazaki M., Nakagawa R., Fukuyama H., Nagata S. and Kishimoto T.

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

Proc. Natl. Acad. Sci. U. S. A. 97, 5405-5410. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10792035?

McIlroy D., Tanaka M., Sakahira H., Fukuyama H., Suzuki M., Yamamura K., Ohsawa Y., Uchiyama Y. and Nagata S.

An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes

Genes Dev. 14, 549-558. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10716943?

Matsumura H., Shimizu Y., Ohsawa Y., Kawahara A., Uchiyama Y. and Nagata S.

Necrotic death pathway in Fas receptor signaling

J. Cell Biol. 151, 1247-1255. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/11121439?

Hashimoto H., Shintani N., Nishino A., Okabe M., Ikawa M., Matsuyama S., Itoh K., Yamamoto K., Tomimoto S., Fujita T., Hagihara N., Mori W., Koyama Y., Matsuda T., Nagata S. and Baba A.

Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide

J. Neurochem. 75, 1810-1817. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/11032869?

Cossarizza A., Stent G., Mussini C., Paganelli R., Borghi V., Nuzzo C., Pinti M., Pedrazzi J., Benatti F., Esposito R., Rosok B., Nagata S., Vella S., Franceschi C. and De Rienzo B.

Deregulation of the CD95/CD95L system in lymphocytes from patients with primary acute HIV infection

Aids 14, 345-355. (2000).

http://www.ncbi.nlm.nih.gov/pubmed/10770536?