Publications

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Mol. Cell. Biol. 40(3), e00402-19, Cover

2021

Sakuragi, T., Kanai, R., Tsutsumi, A., Narita, H., Onishi, E., Nishino, K., Miyazaki, T., Baba, T., Kosako, H., Nakagawa, A., Kikkawa, M., Toyoshima, C., and Nagata, S.

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.

Nature Structural & Molecular Biology 28: 825-834, 2021,

Segawa, K., Kikuchi, A., Noji, T., Sugiura, Y., Hiraga, K., Suzuki, C., Haginoya, K., Kobayashi, Y., Matsunaga, M., Ochiai, Y., Yamada, K., Nishimura, T., Iwasawa, S., Shoji, W., Sugihara, F., Nishino, K., Kosako, H., Ikawa, M., Uchiyama, Y., Suematsu, M., Ishikita, H., Kure, S., and Nagata, S.

A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.

Journal of Clinical Investigation 131, e148005, 2021

Caronni, N., Piperno, G., Simoncello, F., Romano, O., Vodret, S., Yanagihashi, Y., Dress, R., Dutertre, C.-A., Bugatti, M., Bourdely, P., Prete, A. D., Schioppa, T., Mazza, E., Collavin, L., Zacchigna, S., Ostuni, R., Guermonprez, P., Vermi, W., Ginhoux, F., Bicciato, S., Nagata, S., and Benvenu, F.

TIM4 on type 1 DCs mediates uptake of tumor-associated antigens and activation of anti tumor responses in lung tumor.

Nat Commun 12: 2237, 2021, DOI: 10.1038/s41467-021-22535-z

Omori, S., Tsugita, M., Hoshikawa, Y., Morita, M., Ito, F., Yamaguchi, S.-I., Xie, Q., Noyori, O., Yamaguchi, T., Takada, A., Saitoh, T., Toyokuni, S., Akiba, H., Nagata, S., Kinoshita, K., and Nakayama, M.

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.

Cell Rep. 34: 108734, 2021

2020

Nakanishi, H., Nishizawa, T., Segawa, K., Nureki, O., Fujiyoshi, Y., Nagata, S., and Abe, K.

Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.

Cell Rep. 32: 108208, 2020

Nagata, S. and Segawa, K.

Sensing and clearance of apoptotic cells

Curr. Opin. Immunol. 68: 1-8, 2020

Nakanishi, H., Irie, K., Segawa, K., Hasegawa, K., Fujiyoshi, Y., Nagata, S., and Abe, K.

Crystal structure of a human plasma membrane phospholipid flippase.

J Biol Chem 295, 10180-10194 (2020).

Ryoden, Y., Fujii, T., Segawa, K., and Nagata, S.

Functional expression of the P2X7 ATP receptor requires Eros.

J. Immunol. Vol. 204, Issue 3 559-568, 2020

Yamashita, Y., Suzuki, C., Uchiyama, Y., and Nagata, S.

Infertility caused by inefficient apoptotic germ cell clearance in Xkr8-deficient male mice.

Mol. Cell. Biol. 40 (3), e00402-19

2019

Nagata, S., Sakuragi, T., and Segawa, K.

Flippase and Scramblase for Phosphatidylserine Exposure.

Curr Opin Immunol 62, 31-38 (2020).

Tsuji T, Cheng J., Tatematsu T., Ebata A., Kamikawa H., Fujita A., Gyobu S., Segawa K., Arai H., Taguchi T., Nagata S., and Fujimoto T.

Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution.

Proc Natl Acad Sci USA 116:13368-13373, 2019

Nishi, C., Yanagihashi, Y., Segawa, K., and Nagata, S.

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation.

J Biol Chem. 294(18): 7221-7230. 2019

Sakuragi, T., Kosako, H., and Nagata, S.

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure.

Proc. Natl. Acad. Sci. USA 116: 2907-2912, 2019

2018

Segawa, K., Yanagihashi, Y., Yamada, K., Suzuki, C., Uchiyama, Y., and Nagata, S.

Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.

Proc. Nat. Acad. Sci. USA: 115(48):12212-12217. 2018

Kawano, M., and Nagata, S.

Efferocytosis and autoimmune disease.

Int. Immunol. 30: 551-558, 2018

Watanabe, R., Sakuragi, T., Noji, H., and Nagata, S.

Single-molecule analysis of phospholipid scrambling by TMEM16F.

Proc. Nat. Acad. Sci. USA: 15: 3066-3071. 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K. M., DeBerardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jaattela, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., Lopez-Otin, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Munoz-Pinedo, C., Nagata, S., Nunez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H. U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G., and Kroemer, G.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Cell Death Differ 25: 486-541. 2018

Kawano, K. and Nagata, S.

Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase

Proc. Natl. Acad. Sci. USA, 115: 2132-2137. 2018

Nagata S.

Apoptosis and clearance of apoptotic cells

Annual Review of Immunology 36: 489-517, 2018

Segawa K, Kurata S, Nagata S.

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane.

J Biol Chem. 293: 2172-2182. 2018

2017

Yanagihashi Y, Segawa K, Maeda R, Nabeshima Y-i, and Nagata S.

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis.

Proc Nat Acad Sci USA 114: 8800-8805.

Gyobu S, Ishihara K, Suzuki J, Segawa K, and Nagata S.

Characterization of the scrambling domain of the TMEM16 family.

Proc. Natl. Acad. Sci. USA 114:6274-6279.

Nagata, S. and Tanaka, M.

Programmed cell death and the immune system.

Nat Rev Immunol 17:333-340

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S., and Kurose, H.

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.

J Clin Invest: 127: 383-401, 2017

2016

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S., and Kurose, H.

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.

J Clin Invest: in press, 2016

Suzuki, J., Imanishi, E., and Nagata, S.

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

Proc. Natl. Acad. Sci. USA 113: 9509-9514, 2016

Sakamoto, K., Fukushima, Y., Ito, K., Matsuda, M., Nagata, S., Minato, N., and Hattori, M.

Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.

J. Immunol. 197: 2177-2186, 2016

Ishihara, K., Suzuki, J. and Nagata, S.

A Role of Ca2+ in the Stability and Function of TMEM16F and 16K.

Biochemistry 55: 3180-3188, 2016

Nagata, S.

Cell biology: Killer enzymes tethered.

Nature 533: 474-476, 2016

Segawa, K., Kurata, S., and Nagata, S.

Human type IV P-type ATPases that work as plasma membrane phospholipid flippases, and their regulation by caspase and calcium.

J. Biol. Chem. 291 (2): 762-772, 2016

Gyobu, S., Miyata, H., Ikawa, M., Yamazaki, D., Takeshima, H., Suzuki, J., and Nagata, S.

A role of TMEM16E carrying a scrambling domain in sperm motility.

Mol. Cell Biol. 36: 645-659, 2016

Nagata, S., Suzuki, J., Segawa, K., and Fujii, T.

Exposure of Phosphatidylserine on the Cell Surface.

Cell Death Differ. 23: 952-961, 2016

2015

Fujii, T., Sakata, A., Nishimura, S., Eto, K., and Nagata, S.

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.

Proc. Natl. Acad. Sci. USA 112 (41): 12800-12805, 2015

Segawa, K., and Nagata, S.

An apoptotic 'eat me' signal: phosphatidylserine exposure.

Trends Cell Biol 25: 649-650, 2015

Toda, S., Nishi, C., Yanagihashi, Y., Segawa, K., and Nagata, S.

Clearance of Apoptotic Cells and Pyrenocytes.

Curr. Top. Dev. Biol. 114: 267-295, 2015

Motani, K., Ito, S., and Nagata, S.

DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.

J Immunol. 194(10):4914-23., 2015

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